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What is Hepcinat-LP?

Hepcinat-LP contains a combination of ledipasvir and sofosbuvir. Ledipasvir and sofosbuvir are antiviral medications that prevent hepatitis C virus (HCV) cells from multiplying in your body.

Hepcinat-LPis used to treat hepatitis C in adults.

Hepcinat-LP may also be used for purposes not listed in this medication guide.

Important information

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not useHepcinat-LP if you are allergic to ledipasvir and sofosbuvir, or if you are also taking sofosbuvir tablets (Sovaldi).

To make sure Harvoni is safe for you, tell your doctor if you have:

  • liver problems other than hepatitis C;
  • kidney disease (or if you are on dialysis); or
  • if you have recently used a heart rhythm medicine called amiodarone (Cordarone, Pacerone).

Hepcinat-LP is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether ledipasvir and sofosbuvir passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Hepcinat-LP is not approved for use by anyone younger than 18 years old.

How should I take Hepcinat-LP?

Take Hepcinat-LP exactly as prescribed by your doctor. Hepcinat-LPis usually taken once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take Hepcinat-LP with or without food. Take the medicine at the same time each day.

While using Hepcinat-LP, you may need frequent blood tests.

Store this medicine in the original container at room temperature away from moisture and heat.

Hepcinat-LP dosing information

Usual Adult Dose for Chronic Hepatitis C:

1 tablet orally once a day

Duration of Therapy:
-Therapy-naive patients without cirrhosis: 12 weeks; 8 weeks can be considered if pretreatment HCV RNA less than 6 million international units/mL
-Therapy-naive patients with cirrhosis: 12 weeks
-Therapy-experienced patients without cirrhosis: 12 weeks
-Therapy-experienced patients with cirrhosis: 24 weeks

-Relapse rates are affected by baseline host and viral factors and differ between durations of therapy for some subgroups.
-Therapy-experienced patients are those patients who have failed treatment with either peginterferon alfa/ribavirin or peginterferon alfa/ribavirin/HCV protease inhibitor.

Use: For the treatment of chronic hepatitis C genotype 1 infection

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical treatment.

What should I avoid while taking Hepcinat-LP?

Avoid taking an antacid within 4 hours before or 4 hours after you take Harvoni. This especially includes antacids that contain aluminum or magnesium (Acid Gone, Aldroxicon, Alternagel, Di-Gel, Gaviscon, Gelusil, Genaton, Maalox, Maldroxal, Milk of Magnesia, Mintox, Mylagen, Mylanta, Pepcid Complete, Rolaids, Rulox, and others).

Taking this medication will not prevent you from passing hepatitis C to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HCV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Hepcinat-LP side effects

Get emergency medical help if you have signs of an allergic reaction to Harvoni: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common Harvoni side effects may include:

  • headache
  • tired feeling.

This is not a complete list of side effects and others may occur. Ask your doctor for medical advice about side effects.

See also: Side effects (in more detail)

What other drugs will affect Hepcinat-LP?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Hepcinat-LP, especially:

  • amiodarone;
  • Atripla (efavirenz, emtricitabine, and tenofovir);
  • digoxin (digitalis);
  • other drugs to treat hepatitis C, such as simeprevir (Olysio) or sofosbuvir (Sovaldi);
  • ritonavir (Norvir) when used with tipranavir (Aptivus);
  • rosuvastatin (Crestor);
  • St. John’s wort;
  • Stribild (elvitegravir, cobicistat, emtricitabine, tenofovir);
  • tenofovir when used in combination with atazanavir, darunavir, lopinavir, or ritonavir;
  • seizure medicine – carbamazepine, oxcarbazepine, phenobarbital, phenytoin;
  • stomach acid reducers – cimetidine (Tagamet), esomeprazole (Nexium), famotidine (Pepcid) lansoprazole (Prevacid), nizatidine (Axid), omeprazole (Prilosec), pantoprazole (Protonix), ranitidine (Zantac), and others; or
  • tuberculosis medicine – rifabutin, rifampin, rifapentine.

This list is not complete. Other drugs may interact with ledipasvir and sofosbuvir, including prescription and OTC medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

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